Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu, Taiwan. Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan. Department of Medicine, MacKay Medical College, New Taipei, Taiwan. Department of Obstetrics and Gynecology, Hsinchu MacKay Memorial Hospital, Hsinchu, Taiwan. Department of Pediatrics, MacKay Children's Hospital, Taipei, Taiwan. Department of Medical Research, Tamsui MacKay Memorial Hospital, New Taipei, Taiwan. Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Institute of Biomedical Sciences, MacKay Medical College, New Taipei, Taiwan. Department of Pediatrics, Changhua Christian Children's Hospital, Changhua, Taiwan. Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.